Growth HormonePeptides5 min read
GHRP-6: The Growth Hormone Releasing Hexapeptide in Fundamental Research
GHRP-6 was one of the first synthetic growth hormone secretagogues. Learn how it works and what current research shows.
Tissue HealingPeptides
BPC-157: The Healing Peptide from Gastric Juice
6 min read
What is BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide isolated from an endogenous protein found in gastric juice. Its sequence of 15 amino acids confers remarkable stability in biological environments and broad activity across various tissue types.
First systematically studied in the 1990s by Professor Predrag Sikiric's research group at the University of Zagreb, BPC-157 has since built an extensive preclinical database covering several hundred animal studies on tendon, muscle, bone and mucosal injuries.
Mechanisms of Action
A central mechanism of BPC-157 is the stimulation of angiogenesis — the formation of new blood vessels. Through upregulation of VEGF (Vascular Endothelial Growth Factor), the peptide substantially improves perfusion in injured tissue. It simultaneously modulates VEGFR2 expression, leading to accelerated vascularisation.
BPC-157 also influences the nitric oxide system (NO system) and shows demonstrable effects on tenoblasts, the precursor cells of tendon connective tissue. Studies on Achilles tendon lesions demonstrated significantly accelerated functional recovery compared to control groups.
Current Research Status
Particularly noteworthy is the systemic activity profile: BPC-157 exerts regenerative effects in distant tissues even with systemic administration, not only locally at the site of application — suggesting overarching regulatory mechanisms that have not yet been fully elucidated.
BPC-157 research remains in the preclinical phase. Human clinical trials are pending. All available data derive from animal and cell models. Studien Peptide provides BPC-157 exclusively for scientific research purposes.