NAD+ 1000mg

NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme present in every living cell, serving as the central hub of cellular energy metabolism and a key substrate for longevity-associated enzymes. As a research compound, lyophilized NAD+ 1000mg enables in vitro and in vivo studies on sirtuin activation, mitochondrial biogenesis, and DNA repair mechanisms.

Clinical Research Overview

• Sirtuins (SIRT1-7): NAD+ is the obligate co-substrate for class III HDACs; SIRT1 and SIRT3 require NAD+ for deacetylase activity regulating mitochondrial function and metabolic homeostasis
• PARP1 activation: NAD+-dependent poly(ADP-ribose) polymerase involved in DNA damage response; NAD+ depletion limits PARP1-mediated repair capacity
• Caloric restriction mimicry: Supplemental NAD+ in aged rodent models restored mitochondrial function comparable to younger controls (Gomes et al., Cell, 2013)
• CD38 inhibition studies: CD38-mediated NAD+ hydrolysis is a major driver of age-related NAD+ decline; preclinical models show NAD+ restoration rescues metabolic phenotypes

Biochemical Properties

• Formula: C21H27N7O14P2 (MW 663.43 g/mol)
• Structure: Adenine + ribose-2'-phosphate + pyrophosphate bridge + ribose + nicotinamide
• Half-life: ~1-2 hours (plasma, systemic); intracellular NAD+ pools are more stable
• Purity: >=99% HPLC; Certificate of Analysis included
• Form: Lyophilized powder; reconstitute with sterile bacteriostatic water

Available for Research

• NAD+ 1000mg - 1 Pack
• NAD+ 1000mg - 2 Pack (3% discount)
• NAD+ 1000mg - 3 Pack (5% discount)

Storage & Handling

• Store lyophilized at -20°C, protected from light and moisture
• Reconstituted solution: stable at 2-8°C for up to 7 days
• Ships with cold chain packaging to maintain integrity
• For research use only — not for human consumption