Tesamorelin

Tesamorelin is a synthetic GHRH analog comprising all 44 amino acids of endogenous growth hormone-releasing hormone, with a trans-3-hexenoic acid modification at the N-terminus that dramatically extends its plasma half-life. It is the only FDA-approved peptide in its class (marketed as Egrifta/Egrifta SV) for reduction of excess abdominal fat in HIV-infected patients with lipodystrophy, and is extensively studied in the context of visceral adipose reduction, body composition, and metabolic research.

Clinical Research Overview

• FDA approval: Tesamorelin (Egrifta) received FDA approval in 2010 for HIV-associated lipodystrophy — the only GHRH analog with regulatory approval in this indication
• Visceral adipose reduction: Multiple Phase III RCTs (LIPO-010, LIPO-011) demonstrated significant reductions in visceral adipose tissue (VAT) vs. placebo; effects reversed upon discontinuation
• IGF-1 elevation: Tesamorelin stimulates pulsatile GH release, which increases hepatic IGF-1 production; IGF-1 normalization associated with improved body composition in clinical studies
• Cognitive research: Emerging Phase II data (Baker et al., JAMA) suggests improvement in verbal memory and executive function in MCI populations via GHRH receptor-mediated IGF-1 effects
• Safety profile: Phase III studies show generally mild AEs; edema, arthralgia, myalgia at high doses; glucose metabolism monitoring recommended in metabolic research models

Biochemical Properties

• Sequence: [Hex]-His-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
• MW: ~5135 Da; receptor target: GHRH-R (pituitary somatotrophs)
• Half-life: ~26-38 minutes (vs. native GHRH ~7 min); N-terminal hexenoyl modification prevents DPP-IV cleavage
• Purity: >=99% HPLC; Certificate of Analysis included
• Form: Lyophilized powder; available in 10mg and 20mg per vial

Available for Research

• Tesamorelin 10mg - 1 Pack
• Tesamorelin 10mg - 2 Pack (3% discount)
• Tesamorelin 10mg - 3 Pack (5% discount)
• Tesamorelin 20mg - 1 Pack
• Tesamorelin 20mg - 2 Pack (3% discount)
• Tesamorelin 20mg - 3 Pack (5% discount)

Storage and Handling

• Store lyophilized at 2-8 degrees Celsius, protected from light
• Reconstituted solution: use within 7 days at 2-8 degrees Celsius
• Ships with cold chain packaging
• For research use only — not for human consumption