TB-500

TB-500 is a synthetic peptide fragment corresponding to the active region of Thymosin Beta-4 (Tβ4), a ubiquitous 43-amino acid protein. The biologically active segment — Ac-SDKP (acetyl-Ser-Asp-Lys-Pro) — drives actin polymerization, cell migration, and angiogenesis, making TB-500 one of the most studied peptides in tissue repair and regeneration research.

Unlike BPC-157, which acts primarily through local NO/VEGF signalling, TB-500 exerts its effects systemically via G-actin sequestration. This drives cytoskeletal remodelling, accelerates keratinocyte and endothelial cell migration, and upregulates VEGF-mediated vascular repair. The ILK-PI3K-Akt pathway provides additional anti-apoptotic signalling, while MMP-2/9 activation supports extracellular matrix remodelling.

Research Overview

TB-500 has been extensively studied across multiple tissue types. Key findings from peer-reviewed research:

• Dermal repair: Goldstein et al. (Ann N Y Acad Sci, 2012) demonstrated accelerated wound closure and dermal healing via Tβ4-mediated keratinocyte migration.
• Cardiac repair: Smart et al. (Nature, 2011) showed de novo cardiomyocyte formation from epicardial progenitor cells activated by Thymosin Beta-4 after cardiac injury.
• Anti-inflammatory: NF-κB pathway modulation reduces local inflammatory signalling, relevant for acute and chronic tissue injury research models.
• Angiogenesis: VEGF upregulation and MMP-2/9 matrix remodelling support neovascularisation in ischaemic tissue research models.

Biochemical Properties

• Amino acid sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Thr-Leu-Lys-Lys-Leu-Gln-Thr-Gly-Leu-Pro-Amin
• Molecular formula: C₂₁₂H₃₅₀N₅₆O₇₈S
• Molar mass: 4,963 g/mol
• Plasma half-life: ~1.5 hours | Effect window: 48–72 hours
• CAS number: 77591-33-4
• Synonyms: Thymosin Beta-4 fragment, TB4, Tβ4, Thymosin β4, RGN-352

Buy TB-500 at Studien Peptide

TB-500 is available as lyophilised powder in a single 10 mg vial, with multi-pack options for extended research protocols:

• 10 mg — 1 Pack
• 10 mg — 2 Pack (save ~3%)
• 10 mg — 3 Pack (save ~5%)

All batches are HPLC-analysed with guaranteed purity of ≥99%. Quality assurance includes mass spectrometry for exact molecular weight confirmation and strict endotoxin testing. A Certificate of Analysis (CoA) is provided with every order.

Worldwide Shipping

Studien Peptide ships worldwide. Lyophilised TB-500 is temperature-stable in unreconstituted form, maintaining molecular integrity during international transit at ambient temperature. After reconstitution with bacteriostatic water, refrigerated storage at 2–8 °C is recommended. This product is for research use only (RUO) and is not intended for human or animal use.