Retatrutide (research code LY3437943) is a next-generation research peptide and the first simultaneous triple agonist of its class. The molecule binds concurrently to three central metabolic receptors: the GIP receptor (glucose-dependent insulinotropic polypeptide), the GLP-1 receptor (glucagon-like peptide-1), and the glucagon receptor (GCG-R).
This unique triple mechanism distinguishes Retatrutide from prior dual agonists such as tirzepatide or mono-agonists such as semaglutide. While GIP and GLP-1 primarily modulate insulin secretion and regulate satiety centrally, additional activation of the glucagon receptor opens an entirely new metabolic pathway — targeting increased basal energy expenditure and mobilisation of hepatic fat reserves.
Clinical Studies
Retatrutide is currently in Phase 3 clinical trials (TRIUMPH programme, Eli Lilly). Key findings from the landmark Phase 2 study published in the New England Journal of Medicine (Jastreboff et al., 2023, PMID 37385275):
- Body weight reduction: Up to 24.2% reduction over 48 weeks in the highest dosage group — exceeding prior agents in obesity and metabolic research.
- Cardiometabolic parameters: Significant improvements in HbA1c, fasting glucose, and lipid profile.
- Liver health: Notable reduction in hepatic fat content — a key endpoint for NAFLD and NASH research models.
Biochemical Properties
- Amino acid sequence: His-Geranylgeranyl-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH₂
- Molecular formula: C₂₂₁H₃₄₂N₄₆O₆₈
- Molar mass: 4,731 g/mol
- Biological half-life: ~6 days (Jastreboff et al., NEJM 2023)
- CAS number: 2381089-83-2
- Synonyms: LY3437943, LY-3437943
Buy Retatrutide at Studien Peptide
Retatrutide is available in four precisely calibrated dosages as lyophilised powder for maximum flexibility across research protocols and dose-finding studies:
Each vial is filled and sealed under strict laboratory conditions. All batches are HPLC-analysed with guaranteed purity of ≥99%. Quality assurance includes mass spectrometry for exact molecular weight confirmation and strict endotoxin testing.
Worldwide Shipping
Studien Peptide ships worldwide. Lyophilised Retatrutide is highly temperature-stable in unreconstituted form, maintaining molecular integrity during international transit at ambient temperature. After reconstitution with bacteriostatic water, refrigerated storage at 2–8 °C is recommended. This product is for research use only (RUO) and is not intended for human or animal use.
