NeuropeptidesAnxiolysis5 min read
Selank: The Anxiolytic Heptapeptide from Russian Research
Selank is a synthetic analogue of the endogenous peptide tuftsin. It was clinically investigated in Russia as an anxiolytic. We explain the science.
NeuropeptidesCognition
Semax: The Neuroprotective ACTH Analogue in Research
5 min read
Semax: From Stroke Drug to Research Peptide
Semax (MEHFPGP, also ACTH(4-7)PGP) is a synthetic heptapeptide derived from adrenocorticotropic hormone (ACTH). It was developed in the late 1980s at the Moscow Institute of Molecular Genetics and is approved in Russia and Ukraine as a nasal spray for the treatment of stroke, TIA and cognitive disorders.
Semax is used as a prescription drug in Russia. In German-speaking countries it is not approved and only available for scientific research purposes.- 💡 Note
Mechanisms of Action: BDNF and Neurotrophin Signalling
The central mechanism of action of Semax is the induction of BDNF (Brain-Derived Neurotrophic Factor) in the hippocampus. BDNF is the most important growth factor for neurons and is crucial for learning processes, memory consolidation and neuronal survival. Dolotov et al. (2006) showed in a study that Semax increases BDNF expression and TrkB receptor density in the hippocampus after intranasal administration.
- BDNF induction in the hippocampus and prefrontal cortex
- Modulation of dopaminergic and serotonergic neurotransmission
- Neuroprotective effects via antioxidative mechanisms
- Improvement of cerebral microcirculation
Research Data from Russian Studies
The clinical evidence base for Semax derives predominantly from Russian and Ukrainian studies that are often methodologically limited by Western standards (small sample sizes, unclear randomisation). Skvortsova et al. (1999) showed in a controlled study in ischaemic stroke improved neurological deficits under Semax versus placebo.
Intranasal vs Subcutaneous: Routes of Administration
Semax is typically administered intranasally as it penetrates poorly through the blood-brain barrier. The intranasal route utilises olfactory transport to achieve higher central concentrations. Subcutaneous administration is also described in research but shows a different pharmacokinetic profile.
Studien Peptide provides Semax as a high-purity lyophilised peptide for authorised scientific research laboratories. Not for self-medication.- ⚗️ Research note