Tirzepatide

Tirzepatide (LY3298176) is a 39-amino acid synthetic peptide that functions as a dual agonist at both the GLP-1 receptor (GLP-1R) and the glucose-dependent insulinotropic polypeptide receptor (GIPR). This novel mechanism of action, combined with a fatty acid conjugation enabling weekly subcutaneous dosing, has produced some of the most compelling clinical trial data in metabolic research. It is FDA-approved as Mounjaro (T2DM) and Zepbound (obesity).

Clinical Research Overview

• SURMOUNT-1/2 (obesity): Tirzepatide at 15mg/week produced mean weight reduction of -20.9% from baseline vs. -3.1% placebo (SURMOUNT-1, NEJM 2022); SURMOUNT-2 in T2DM confirmed -15.7% weight reduction
• SURPASS trials (T2DM): Series of 8 RCTs demonstrated superior HbA1c reduction vs. semaglutide, insulin degludec, and placebo across diverse populations
• Dual agonism mechanism: GIPR agonism complements GLP-1R effects — GIP independently stimulates insulin secretion in a glucose-dependent manner and promotes adipogenesis inhibition; combined signaling produces additive metabolic effects
• Cardiovascular outcomes: SURMOUNT-OSA demonstrated 63% reduction in AHI in obstructive sleep apnea; cardiovascular outcomes data pending from SURPASS-CVOT
• Non-alcoholic fatty liver: Phase II data showing significant reductions in liver fat content (CAP score) and liver stiffness

Biochemical Properties

• Sequence: Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Aib-Leu-Asp-Lys(palmitoyl-gamma-Glu-2xOEG)-Gln-Ile-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-NH2
• MW: ~4813 Da; dual receptor targets: GLP-1R and GIPR
• Half-life: ~5 days (C18 fatty acid enables weekly dosing via albumin binding)
• Purity: >=99% HPLC; Certificate of Analysis included
• Available in 10mg and 60mg per vial

Available for Research

• Tirzepatide 10mg - 1 Pack
• Tirzepatide 10mg - 2 Pack (3% discount)
• Tirzepatide 10mg - 3 Pack (5% discount)
• Tirzepatide 60mg - 1 Pack
• Tirzepatide 60mg - 2 Pack (3% discount)
• Tirzepatide 60mg - 3 Pack (5% discount)

Storage and Handling

• Store lyophilized at 2-8 degrees Celsius, protected from light
• Reconstituted solution: use within 7 days at 2-8 degrees Celsius
• Ships with cold chain packaging
• For research use only — not for human consumption