HGH Fragment 176–191

AOD-9604 (HGH Fragment 176–191) is a synthetic peptide corresponding to amino acids 176–191 of human growth hormone. It selectively activates beta-3 adrenergic receptors in adipose tissue, stimulating lipolysis without the hyperglycemic or mitogenic effects of full-length GH. Supplied as ≥99% pure lyophilized powder for in vitro and preclinical research.

Research Overview

• Selective beta-3 AR-mediated lipolysis in adipose tissue without altering blood glucose (Heffernan et al., 2001)
• Inhibition of lipogenesis from dietary carbohydrates and fat in animal models (Ng & Waters, 2004)
• Equivalent lipolytic activity to full-length GH at significantly lower doses in preclinical studies
• No observed impact on IGF-1 levels, insulin sensitivity, or cartilage growth in research models
• Favorable safety profile in Phase I/II human trials conducted by Metabolic Pharmaceuticals (Australia)

Biochemical Properties

• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
• Molecular Weight: ~1,815 Da
• Half-Life: Minutes (plasma); subcutaneous administration extends bioavailability
• Form: Lyophilized powder, ≥99% purity (HPLC-verified)
• CAS Number: 221231-10-3

Purchase AOD-9604 for Research

Studien Peptide supplies AOD-9604 (HGH Fragment 176–191) as 10 mg lyophilized vials at ≥99% purity for licensed research institutions and investigators.

Shipping & Storage

AOD-9604 ships via cold-chain transport. Lyophilized peptides are temperature-controlled throughout shipping and arrive with a Certificate of Analysis. Store at 2–8 °C upon receipt.