Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as an analog of the endogenous immunopeptide tuftsin. It allosterically modulates GABA-A receptors, upregulates BDNF and NGF expression, and stabilizes enkephalins, producing anxiolytic and nootropic effects without sedation or dependence. Supplied as ≥99% pure lyophilized powder for in vitro and preclinical research.
Research Overview
- Anxiolytic without sedation: GABA-A allosteric enhancement reduces anxiety-like behavior in rodent models without the tolerance or dependence seen with benzodiazepines (Semenova et al., 2010)
- Nootropic effects: Improves memory consolidation and learning performance in preclinical models via BDNF and NGF upregulation
- Enkephalin stabilization: Inhibits enkephalin-degrading enzymes, enhancing endogenous opioid tone without direct opioid receptor agonism
- Immunomodulation: As a tuftsin analog, modulates IL-6, TNF-α, and interferon expression in immune research models
- Neuroprotection: Attenuates oxidative stress and neuroinflammatory markers in CNS injury models
Biochemical Properties
- Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
- Molecular Weight: 751.90 Da
- Half-Life: ~2–3 minutes (plasma); active metabolites persist for hours
- Form: Lyophilized powder, ≥99% purity (HPLC-verified)
- CAS Number: 129954-34-3
Purchase Selank for Research
Studien Peptide supplies Selank as 10 mg lyophilized vials at ≥99% purity for licensed research institutions and investigators. Volume options available.
- Selank 10mg - 1 Pack
- Selank 10mg - 2 Pack (3% discount)
- Selank 10mg - 3 Pack (5% discount)
Shipping & Storage
Selank ships via cold-chain transport. Lyophilized peptides are temperature-controlled throughout shipping and arrive with a Certificate of Analysis. Store at 2–8 °C upon receipt.
