GHK-Cu

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring tripeptide-copper chelate first isolated from human plasma by Dr. Loren Pickart. It activates tissue remodeling genes, stimulates collagen and elastin synthesis, and exhibits potent antioxidant and anti-inflammatory activity. Supplied as ≥99% pure lyophilized powder for in vitro and preclinical research.

Research Overview

• Collagen Remodeling: stimulates synthesis of collagen types I, III, and V; upregulates MMP expression for ECM turnover (Pickart et al., 2012)
• Wound Healing: accelerates wound closure and tissue regeneration via TGF-β and VEGF modulation in preclinical models
• Antioxidant Defense: induces superoxide dismutase (SOD) and catalase expression, reducing oxidative stress markers in vitro
• Neuroprotective Effects: promotes BDNF expression and neurite outgrowth in preclinical nerve regeneration studies
• Anti-Inflammatory Activity: suppresses IL-6, TNF-α, and NF-κB signaling in inflammatory research models

Biochemical Properties

• Sequence: Gly-His-Lys-Cu²⁺ (glycyl-L-histidyl-L-lysine copper(II) complex)
• Molecular Weight: ~340 Da (peptide); ~404 Da (copper complex)
• Half-Life: ~30 minutes (plasma)
• Form: Lyophilized powder, ≥99% purity (HPLC-verified)
• CAS Number: 89030-95-5

Purchase GHK-Cu for Research

Studien Peptide supplies GHK-Cu as 50 mg lyophilized vials at ≥99% purity for licensed research institutions and investigators. Volume options available.

• GHK-Cu 50mg - 1 Pack
• GHK-Cu 50mg - 2 Pack (3% discount)
• GHK-Cu 50mg - 3 Pack (5% discount)

Shipping & Storage

GHK-Cu ships via cold-chain transport. Lyophilized peptides are temperature-controlled throughout shipping and arrive with a Certificate of Analysis. Store at 2–8 °C upon receipt.