Melanotan II

Melanotan II (MT-2) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). It acts as a non-selective melanocortin receptor agonist (MC1R–MC5R), making it a widely used tool in research on skin pigmentation, appetite regulation, and melanocortin system biology. Supplied as ≥99% pure lyophilized powder for in vitro and preclinical research.

Research Overview

• Pigmentation: MC1R agonism stimulates eumelanin synthesis in melanocytes, driving skin and hair darkening in preclinical and early clinical studies (Dorr et al., 1996)
• Appetite Regulation: MC3R/MC4R activation suppresses food intake in rodent models; studied as a tool compound for hypothalamic appetite circuits (Brinster et al., 2020)
• Erectile Function Research: MC4R-mediated pro-erectile effects documented in preclinical models; led to development of bremelanotide (PT-141)
• Anti-inflammatory Effects: MC1R and MC3R activation shown to reduce NF-κB-mediated inflammatory signaling in several cell models
• Extended Plasma Half-Life: cyclic structure and D-Phe substitution confer ~33–36 h plasma half-life vs. minutes for native α-MSH

Biochemical Properties

• Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ (cyclic heptapeptide)
• Molecular Weight: 1,024 Da
• Half-Life: ~33–36 hours (plasma)
• Form: Lyophilized powder, ≥99% purity (HPLC-verified)
• CAS Number: 121062-08-6

Purchase Melanotan II for Research

Studien Peptide supplies Melanotan II (MT-2) as 10 mg lyophilized vials at ≥99% purity for licensed research institutions and investigators. Volume options available.

• Melanotan II 10mg - 1 Pack
• Melanotan II 10mg - 2 Pack (3% discount)
• Melanotan II 10mg - 3 Pack (5% discount)

Shipping & Storage

Melanotan II ships via cold-chain transport. Lyophilized peptides are temperature-controlled throughout shipping and arrive with a Certificate of Analysis. Store at 2–8 °C upon receipt.