Semax

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide and analog of the adrenocorticotropic hormone fragment ACTH(4–10). Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it potently upregulates BDNF and NGF expression, enhances neuroprotection, and improves cognitive function in preclinical models. Supplied as ≥99% pure lyophilized powder for in vitro and preclinical research.

Research Overview

• BDNF & NGF Upregulation: Semax significantly increases expression of Brain-Derived and Nerve Growth Factors in hippocampal and cortical neurons, supporting synaptic plasticity (Kolomin et al., 2013)
• Cognitive Enhancement: Improves spatial memory, attention, and learning performance in rodent models across multiple experimental paradigms
• Neuroprotection: Attenuates ischemic neuronal damage and reduces neuroinflammatory markers (TNF-α, IL-1β) in stroke models
• Anxiolytic Effects: Modulates dopaminergic and serotonergic signaling, reducing anxiety-like behavior without sedation in preclinical studies
• Opioid System Modulation: Stabilizes enkephalins by inhibiting enkephalinase activity, enhancing endogenous opioid tone

Biochemical Properties

• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
• Molecular Weight: 887.03 Da
• Half-Life: ~30–40 minutes (plasma); effects persist for several hours
• Form: Lyophilized powder, ≥99% purity (HPLC-verified)
• CAS Number: 80714-61-0

Purchase Semax for Research

Studien Peptide supplies Semax as 10 mg lyophilized vials at ≥99% purity for licensed research institutions and investigators. Volume options available.

• Semax 10mg - 1 Pack
• Semax 10mg - 2 Pack (3% discount)
• Semax 10mg - 3 Pack (5% discount)

Shipping & Storage

Semax ships via cold-chain transport. Lyophilized peptides are temperature-controlled throughout shipping and arrive with a Certificate of Analysis. Store at 2–8 °C upon receipt.