NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme present in every living cell, serving as the central hub of cellular energy metabolism and a key substrate for longevity-associated enzymes. As a research compound, lyophilized NAD+ 1000mg enables in vitro and in vivo studies on sirtuin activation, mitochondrial biogenesis, and DNA repair mechanisms.
Clinical Research Overview
- Sirtuins (SIRT1-7): NAD+ is the obligate co-substrate for class III HDACs; SIRT1 and SIRT3 require NAD+ for deacetylase activity regulating mitochondrial function and metabolic homeostasis
- PARP1 activation: NAD+-dependent poly(ADP-ribose) polymerase involved in DNA damage response; NAD+ depletion limits PARP1-mediated repair capacity
- Caloric restriction mimicry: Supplemental NAD+ in aged rodent models restored mitochondrial function comparable to younger controls
- CD38 inhibition studies: CD38-mediated NAD+ hydrolysis is a major driver of age-related NAD+ decline; NAD+ restoration rescues metabolic phenotypes
Biochemical Properties
- Formula: C21H27N7O14P2 (MW 663.43 g/mol)
- Half-life: ~1-2 hours (plasma, systemic)
- Purity: >=99%% HPLC; Certificate of Analysis included
- Form: Lyophilized powder
Available for Research
- NAD+ 1000mg - 1 Pack
- NAD+ 1000mg - 2 Pack
- NAD+ 1000mg - 3 Pack
Storage and Handling
- Store lyophilized at -20 degrees Celsius, protected from light
- Reconstituted: stable at 2-8 degrees Celsius up to 7 days
- Ships with cold chain packaging
- For research use only